Spatiotemporal Single-Cell Transcriptomics Reveals Aberrant Neuroimmune Interactions Driving Early Pathogenesis in Alzheimer’s Disease
Keywords:
Alzheimer’s disease, single-cell transcriptomics, spatial transcriptomics, neuroimmune interaction, microglia, astrocytes, neuroinflammationAbstract
Recent advances in single-cell and spatial transcriptomics allow the investigation of cellular heterogeneity and microenvironmental interactions at unprecedented resolution. In this study, we applied spatiotemporal single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics to brain tissue from early-stage Alzheimer's disease (AD) models. Our findings reveal disrupted neuroimmune interactions, with microglia and astrocytes showing aberrant activation states linked to neuronal vulnerability. Key pathways involved include complement signaling, interferon response, and cytokine-mediated neuroinflammation. These results highlight early neuroimmune dysregulation as a central feature of AD pathogenesis and a promising avenue for therapeutic intervention.
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Copyright (c) -1 Bertram Asbjørn (Author)
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