Molecular Mechanisms of DNA Replication, Repair, and Recombination in Eukaryotic Cells
Keywords:
DNA replication, DNA repair, DNA recombination, eukaryotic cells, genome stability, DNA damage response, cell divisionAbstract
DNA replication, repair, and recombination are fundamental processes in eukaryotic cells that ensure genome stability and integrity. The coordination of these processes is essential for cell division, DNA damage response, and the preservation of genetic information across generations. This paper reviews the molecular mechanisms underlying these processes, highlighting key enzymes, proteins, and regulatory pathways involved in DNA replication, repair, and recombination. Recent advancements in our understanding of the molecular details of these mechanisms are discussed, with a focus on their relevance to disease prevention and therapeutic strategies. The integration of these processes ensures the faithful transmission of genetic material, protecting the organism from genetic instability and disease.
References
Alberts, Bruce, et al. Molecular Biology of the Cell. 6th ed., Garland Science, 2015.
Jackson, Stephen P., and Jurgen Bartek. "The DNA-Damage Response in Human Biology and Disease." Nature, vol. 461, no. 7267, 2009, pp. 1071-1078.
Sankaran, Subramaniam, and James E. Haber. "DNA Recombination and Repair." Nature Reviews Genetics, vol. 8, no. 3, 2007, pp. 206-220.
Shiloh, Yoram. "ATM and Related Protein Kinases: Safeguarding Genome Integrity." Nature Reviews Cancer, vol. 3, no. 3, 2003, pp. 155-168.
Rassool, Fawzi V., and Shelley A. Isaacs. "Targeting DNA Repair in Cancer." Nature Reviews Drug Discovery, vol. 17, no. 11, 2018, pp. 781-795.
Stillman, Brian. "Origin Recognition and Unwinding of DNA." Cell, vol. 64, no. 3, 1991, pp. 513-516.
Kunkel, Thomas A., and Peter A. S. Bebenek. "DNA Replication Fidelity." Annual Review of Biochemistry, vol. 67, 1998, pp. 497-529.
Lindahl, Tomas, and Peter M. Wood. "Quality Control of DNA Replication." Cell, vol. 58, no. 5, 1989, pp. 759-768.
Jasin, Maria. "Homologous Repair of Double-Strand Breaks." Cell, vol. 83, no. 6, 1995, pp. 1041-1044.
Karch, Christina P., and Michael P. Lisanti. "Nucleotide Excision Repair and the Cellular Response to UV-Induced DNA Damage." Biochemical Journal, vol. 356, no. 2, 2001, pp. 345-358.
Sancar, Aziz, et al. "DNA Repair in Eukaryotes: Mechanisms and Relevance to Human Disease." Journal of Biological Chemistry, vol. 276, no. 22, 2001, pp. 22913-22916.
Vilenchik, Mikhail M., and A. L. Knudson. "Endogenous DNA Damage as the Driver of Aging." Nature Reviews Molecular Cell Biology, vol. 6, no. 9, 2005, pp. 762-773.
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