Soft Electronics for Skin-Mounted Biosensing and Physiological Therapeutic Feedback Systems

Authors

  • Carlos Widget Biotechnologist, USA Author

Keywords:

Soft electronics, biosensors, wearable systems, skin-mounted devices, physiological monitoring, therapeutic feedback, flexible electronics, closed-loop therapy, electronic skin, biointerface

Abstract

The convergence of soft electronics, biosensing, and physiological therapeutic feedback systems has revolutionized modern health monitoring and therapeutic intervention strategies. These skin-mounted systems, designed for mechanical compliance with the human epidermis, enable real-time, multimodal, and wireless physiological sensing with minimal invasiveness. Advances in materials science, microfabrication, and data integration have enabled sensors capable of detecting biophysical (temperature, strain, ECG), biochemical (sweat glucose, lactate), and electrophysiological (EEG, EMG) signals. Concurrently, feedback mechanisms—such as electrical stimulation, drug delivery, and thermal therapy—allow adaptive therapeutic response. This paper explores the latest progress in skin-conformal electronics, evaluates materials and architectures used in biosensing and feedback systems, and discusses future directions, including AI integration and closed-loop therapy.

References

Bao, Zhenan, et al. “Skin-Inspired Soft Bioelectronic Materials, Devices and Systems.” Nature Reviews Bioengineering, vol. 1, 2024, pp. 113–130.

Choi, Chul, et al. “Wearable and Implantable Soft Bioelectronics Using Two-Dimensional Materials.” Accounts of Chemical Research, vol. 51, no. 5, 2018, pp. 1111–1120.

Haick, Hossam, et al. “Skin Bioelectronics Towards Long-Term, Continuous Health Monitoring.” Chemical Society Reviews, vol. 51, no. 1, 2022, pp. 152–175.

Lee, Eun Kyu, et al. “Skin-Mountable Biosensors and Therapeutics: A Review.” Annual Review of Biomedical Engineering, vol. 21, 2019, pp. 113–145.

Lin, Mengjia, et al. “Soft Wearable Devices for Deep-Tissue Sensing.” Nature Reviews Materials, vol. 7, 2022, pp. 850–870.

Wu, Huanyu, et al. “Materials, Devices and Systems of Soft Bioelectronics for Precision Therapy.” Advanced Healthcare Materials, vol. 6, no. 8, 2017, Article 1700017.

Xu, Kuniharu, et al. “Multifunctional Skin-Inspired Flexible Sensor Systems for Wearable Electronics.” Advanced Materials Technologies, vol. 4, no. 4, 2019, Article 1800628.

Zhao, Chong, et al. “Recent Advances in Soft Electronics for Physiological Monitoring and Therapy.” Nature Reviews Bioengineering, vol. 1, 2024, pp. 1–20.

Gong, Shaojiang, et al. “Materials-Driven Soft Wearable Bioelectronics for Connected Healthcare.” Chemical Reviews, vol. 124, no. 6, 2024, pp. 3421–3465.

Guo, Xiaoyu, et al. “Flexible Electronics with Dynamic Interfaces for Biomedical Monitoring, Stimulation, and Characterization.” International Journal of Mechanical System Dynamics, vol. 3, no. 1, 2021, pp. 1–15.

Kim, Haejin, et al. “Advances in Ultrathin Soft Sensors, Integrated Materials, and Manufacturing Technologies for Enhanced Monitoring of Human Physiological Signals.” Advanced Electronic Materials, vol. 9, no. 3, 2023, Article 2201294.

Liu, Yifan, et al. “Lab-on-Skin: A Review of Flexible and Stretchable Electronics for Wearable Health Monitoring.” ACS Nano, vol. 11, no. 10, 2017, pp. 9614–9635.

Rao, Zhaojun, et al. “Soft Electronics for the Skin: From Health Monitors to Human–Machine Interfaces.” Advanced Materials Technologies, vol. 5, no. 8, 2020, Article 2000233.

Lyu, Qing, et al. “Soft Wearable Healthcare Materials and Devices.” Advanced Healthcare Materials, vol. 10, no. 3, 2021, Article 2000577.

Chung, Hyeon-U., et al. “Skin-Interfaced Biosensors for Advanced Wireless Physiological Monitoring in Neonatal and Pediatric Intensive-Care Units.” Nature Medicine, vol. 26, no. 3, 2020, pp. 418–429.

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Published

2025-07-07