Self-Powered Bioelectronic Sensors Using Enzymatic Biofuel Cell Integration Techniques

Authors

  • Ms. Padma Priya Biosensor Engineer, India. Author

Keywords:

Self-powered biosensors, Enzymatic biofuel cells, Bioelectronics, Nanomaterials, Glucose oxidation, Implantable sensors, Energy harvesting

Abstract

The convergence of bioelectronics and enzymatic biofuel cell (EBFC) technology has enabled the development of self-powered biosensors that eliminate the need for conventional batteries. These systems harness biochemical reactions between enzymatic catalysts and biofuels such as glucose or lactate to generate electricity. The resulting energy is used to power integrated bioelectronic sensors, facilitating autonomous, miniaturized, and sustainable biomedical devices.

Recent advances in electrode nanomaterials, immobilization strategies, and system-level integration have significantly enhanced EBFC efficiency, stability, and biocompatibility. Applications span from wearable biosensors for real-time health monitoring to implantable devices for chronic disease management. This paper provides a comprehensive review of EBFC-powered bioelectronics, with emphasis on material platforms, fabrication strategies, therapeutic applications, and future prospects for personalized healthcare.

References

Katz, Evgeny, and Itamar Willner. "A Biofuel Cell with Electrodes Modified by Enzyme-DNA Bioconjugates." Journal of the American Chemical Society, vol. 125, no. 22, 2003, pp. 6803–6813.

Xu, Feng, et al. "Graphene–Hydrogel Hybrid Materials for Bioelectronics." Nano Today, vol. 19, 2018, pp. 41–65.

Wang, Shuo, et al. "Lactate-Powered Enzymatic Biofuel Cells for Wearable Applications." Biosensors and Bioelectronics, vol. 150, 2020, pp. 111–118.

Geim, Andre K., and Konstantin S. Novoselov. "The Rise of Graphene." Nature Materials, vol. 6, no. 3, 2007, pp. 183–191.

Shi, Jian, et al. "Advances in Bioelectronic Interfaces Using Hydrogel Composites." Advanced Science, vol. 7, no. 20, 2020, pp. 2001759.

Zhang, Yanan, et al. "Implantable Enzymatic Biofuel Cells for Glucose Monitoring." ACS Nano, vol. 12, no. 4, 2018, pp. 3374–3380.

Liu, Yuchen, et al. "Hybrid Enzymatic Biofuel Cells for Biomedical Applications." Accounts of Chemical Research, vol. 52, no. 12, 2019, pp. 3213–3224.

Kim, Jihye, et al. "Soft Wearable Biosensors for Continuous Monitoring." Advanced Functional Materials, vol. 27, no. 1, 2017, pp. 1604373.

Yuk, Hyunwoo, et al. "Hydrogel Bioelectronics." Chemical Society Reviews, vol. 48, no. 6, 2019, pp. 1642–1667.

Bandodkar, Amay J., et al. "Epidermal Tattoo Biosensors." Nature Biotechnology, vol. 34, no. 6, 2016, pp. 591–598.

Huang, Yu, et al. "Flexible Electronics with Graphene and Hydrogels." Progress in Materials Science, vol. 105, 2019, pp. 100576.

Li, Jian, et al. "Glucose Oxidase-Based Biofuel Cells in Drug Delivery." Advanced Materials, vol. 28, no. 33, 2016, pp. 6227–6239.

Xu, Feng, et al. "Microfluidic Biofuel Cells for Biosensing Applications." Lab on a Chip, vol. 17, no. 12, 2017, pp. 2146–2155.

Heikenfeld, Jason, et al. "Wearable Sensors: Modalities, Challenges, and Prospects." Lab on a Chip, vol. 18, no. 2, 2018, pp. 217–248.

Rogers, John A., et al. "Materials and Mechanics for Stretchable Electronics." Science, vol. 327, no. 5973, 2010, pp. 1603–1607.

Downloads

Published

2024-07-03